Recent advances in nano-targeting drug delivery systems for rheumatoid arthritis treatment

نویسندگان

چکیده

Rheumatoid arthritis is a systemic inflammatory disease that can lead to articular cartilage destruction and periarticular bone erosion, thus ultimately compromising joint integrity function. Anti-inflammatory drugs biological agents are commonly used treat rheumatoid arthritis, but they cannot selectively target inflamed joints, because of their mechanisms, short half-lives low bioavailability. Consequently, these must be at high doses delivered frequently, thereby increasing costs the risk adverse effects. Drug delivery systems, such as nanoparticles, liposomes micelles, significantly prolong drug half-life in body enable targeted into joints. In this review, we comprehensively describe pathogenesis clinical diagnosis summarize recent advances therapeutic strategies, particularly nano-targeting systems for arthritis.

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ژورنال

عنوان ژورنال: Acta Materia Medica

سال: 2023

ISSN: ['2737-7946']

DOI: https://doi.org/10.15212/amm-2022-0039